Clinical scenario : A 77-year-old female presented to our hospital with history of lower GI bleed and colonoscopic examination showed multiple lesions in sigmoid colon and in transverse colon . Fig 1 and Fig 2 Biopsy was taken . Fig.1 Multiple lesions seen on colonoscopy Fig2 Multiple lesions seen The biopsy revealed features of monotonous sheets of Lymphocytes as shown in figure 3 .The immuno staining was positive for Cyclin D+ and CD 2 positive Fig 4 and 5 below The overall features were suggestive of MANTLE CELL LYMPHOMA (MCL) Fig 4 Immunocytochemistry Cyclin D + Fig 3 sheets of lymphocytes seen Fig.5 Lymphocytes positive for CD2 Further reading : Extra nodal lymphomas commonly occur in the GI tract. They account for 2% of primary GI tract lymphomas . Non-Hodgkin’s lymphoma of the colon is rare . MCL is a discrete entity, unrelated to small lymphocytic or small-cleaved-cell lymphomas . Abdominal pain is the most common symptom
Clinical Blog : Dr Ibrahim Masoodi DM(Gastro)FACG ,FASGE Associate Professor of Gastroenterology Yenepoya University Medical College Mangalore ,Karnataka